scourge [skɜ:dʒ]

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n.灾难，祸害；vt.蹂躏

something or someone that causes great suffering or a lot of trouble

Smallpox was once the scourge of the world. 天花曾是世界的大患。
The new boss was the scourge of the inefficient. 新老板来了以后，不称职的人就遭殃了。