marrow [ˈmærəʊ]

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n.骨髓；精华；活力

soft tissue containing a lot of fat in the centre of a bone

It was so cold that he felt frozen to the marrow. 天气太冷了，他感到寒冷刺骨。
He was tired to the marrow of his bones. 他真是累得筋疲力尽了。