irritate [ˈɪrɪteɪt]

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vt.使恼怒，使烦燥，使不适，使疼痛

to make angry or annoyed

Don't irritate her, she's on a short fuse today. 别惹她，她今天动不动就发火。
These tight shoes irritate my toes. 我的鞋太紧，夹痛我的脚趾。